The sequestration of white blood cells and the parasite-infected red blood cells may result in the blockage of the microvasculature as well as a reduction in the oxygen content of the tissues. Proteins may also be transported to the exterior of the affected red blood cells. Such protein-coated red blood cells tend to stick to the inner surface (endothelium) of the blood vessels and in so doing slow down their elimination by the spleen. While trying to get rid of infected red blood cells, the bodyâ€™s immune system may also eliminate uninfected erythrocytes. Such nonhemolytic machinery also worsens anemia in patients suffering from babesiosis.
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