The effect of loss of pressure and concentration of oxygen is well illustrated in a plane mishap that occurred on October 25thÂ 1999, which occurred at Aberdeen South of Dakota. The details and investigations 0f this accident are contained in an NTSB database accident no. DCA00MA005. Investigations revealed that this crash was caused by the hypoxia of the pilots and all crewmembers. Observation of the wreckage revealed that the oxygen bottle had malfunctioned. Moreover, sample tests of the captain tissues showed large concentrations of chemicals that occur during oxidation in limited amounts of oxygen. (NTSB, 1999)
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