The biological and structural features also influence the previous inï¬‚ammatory reaction, cell repositioning, accumulation of neo-extracellular matrix, dilapidation of the biomaterial structures, new extracellular matrix growth, mineralization, vascularization, and functionality characteristics at the reconstructed or restored tissue points. Different methods of bio material construction have been created to cater for the clinical requirement for bone healing, regeneration and renewal (Rios et al. 2009).
Both structural design and chemical configuration are constraints that have been considered for managing bone formation complexities in vivo and in vitro (Christenson 2007; de Oliveira et al. 2007; James et al. 2011). The most recent method of engineering biomaterial architecture is constructing nano-meter scale characteristic size material in a macro-scale defect size-based model. This literature review summarizes current empirical designs of nano-biomaterials, cell interactions with these nano-composites or nano-materials, and bone reconstruction utilizing the nano-designed bio-tissues.
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