Hyperacute rejection occurs within a short time posttransplantation, sometimes taking even minutes. This kind of rejection is common among patients who already have prior sensitization and thus they have human leukocyte antigen (HLA) or ABO already present in their circulation. Such patients may also be having any other form of alloantibody which may be sensitive to the donorâ€™s surface antigen. Darkening of the kidney and change into cyanotic is seen during implantation and this is usually associated with renal artery anastomosis. The kidney parenchyma is usually at risk of full hemorrhagic infarction if time goes on without taking the action of removing the kidney.
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