Epigenetics of Bipolar Disorder

Bipolar disorder is an episodic sickness characterized by depression and periodic mood elevation. The etiopathology of bipolar disorder is linked to environmental factors that exert stress on brain function via epigenetic influence, particularly DNA methylation and histone proteins modifications (Schmitt, Malchow, Hasan, & Falkai, 2014). Studies have shown discrepancies in methylation of GPR24 and CTNNA2 genes, which are implicated in psychosis. Maternal and paternal methylation of X-allele has been implicated as the cause of discordance in BPD in twins. Studies of epigenetics of neurotransmission have attributed the hypermethylation of SLC6A4 gene in BPD lymphoblastoid cells of bipolar individuals at two CpG sites. The hypermethylation of SLC6A4 is correlated with SLC6A4 mRNA levels in individuals with S/S genotype of HTTLPR who have less expression suggesting that environmental factors play a partial role in the pathophysiology of BPD (Kang et al., 2013). Serotonin receptor subtype 1A (5HTR1A) found in the cortico-limbic regions of the brain has a high epigenetic alteration in BPD individuals leading to altered neurotransmitter binding (Teroganova et al., 2016). There is an increase in methylation of genes encoding 5HTR1A in the brain of a bipolar individual. Genome-wide studies have revealed important hypomethylation of CpG island of human leukocyte antigen 9 gene (HCG9) in bipolar patients. This gene is found on chromosome 6, which is associated with bipolar disorder (Kaminsky et al., 2012).

Don't use plagiarized sources. Get Your Custom Essay on
Epigenetics of Bipolar Disorder
Just from $13/Page
Order Essay
Assignment Help Guys
Calculate your paper price
Pages (550 words)
Approximate price: -

Why Work with Us

Top Quality and Well-Researched Papers

We always make sure that writers follow all your instructions precisely. You can choose your academic level: high school, college/university or professional, and we will assign a writer who has a respective degree.

Professional and Experienced Academic Writers

We have a team of professional writers with experience in academic and business writing. Many are native speakers and able to perform any task for which you need help.

Free Unlimited Revisions

If you think we missed something, send your order for a free revision. You have 10 days to submit the order for review after you have received the final document. You can do this yourself after logging into your personal account or by contacting our support.

Prompt Delivery and 100% Money-Back-Guarantee

All papers are always delivered on time. In case we need more time to master your paper, we may contact you regarding the deadline extension. In case you cannot provide us with more time, a 100% refund is guaranteed.

Original & Confidential

We use several writing tools checks to ensure that all documents you receive are free from plagiarism. Our editors carefully review all quotations in the text. We also promise maximum confidentiality in all of our services.

24/7 Customer Support

Our support agents are available 24 hours a day 7 days a week and committed to providing you with the best customer experience. Get in touch whenever you need any assistance.

Try it now!

Calculate the price of your order

Total price:

How it works?

Follow these simple steps to get your paper done

Place your order

Fill in the order form and provide all details of your assignment.

Proceed with the payment

Choose the payment system that suits you most.

Receive the final file

Once your paper is ready, we will email it to you.

Our Services

No need to work on your paper at night. Sleep tight, we will cover your back. We offer all kinds of writing services.


Essay Writing Service

No matter what kind of academic paper you need and how urgent you need it, you are welcome to choose your academic level and the type of your paper at an affordable price. We take care of all your paper needs and give a 24/7 customer care support system.


Admission Essays & Business Writing Help

An admission essay is an essay or other written statement by a candidate, often a potential student enrolling in a college, university, or graduate school. You can be rest assurred that through our service we will write the best admission essay for you.


Editing Support

Our academic writers and editors make the necessary changes to your paper so that it is polished. We also format your document by correctly quoting the sources and creating reference lists in the formats APA, Harvard, MLA, Chicago / Turabian.


Revision Support

If you think your paper could be improved, you can request a review. In this case, your paper will be checked by the writer or assigned to an editor. You can use this option as many times as you see fit. This is free because we want you to be completely satisfied with the service offered.

error: Content is protected !!
Open chat
Need assignment help? You can contact our live agent via WhatsApp using +1 718 717 2861

Feel free to ask questions, clarifications, or discounts available when placing an order.