Epidermal substitutes are used for treating lesions that have affected the dermis

The procedure is relatively complicated, but the desired and effective results are usually achieved. Both epidermal and dermal tissues of the skin are used in the materials and methods part of the procedure. Epidermal substitutes are used for treating lesions that have affected the dermis. They contain autologous keratinocytes that are obtained and cultured in cell cultures in the laboratory and in the presence of murine fibroblasts (Horch 599). First, a skin biopsy extending some 2 to 5 cm2 is obtained. Secondly, the dermis and epidermis tissues sections are separated from each other. Third, the keratinocytes are isolated and cultured, which takes about 3 weeks to culture in an appropriate medium (Bartholomew et al. 45). Since this time is relatively long, the patient must be treated with a temporary dressing to protect the wounds and the tissues involved and stimulate their healing process. However, current technologies allow for direct spraying of the biopsy cells directly into the wound, which makes it possible for local delivery of the cells. However, this technique is not recommended for third-degree burn wounds. Recent techniques have made it possible to treat third-degree wounds within a short time through application of cultured keratinocytes. For instance, surface-functionalized polymer discs make it possible for the delivery of cultured autologous keratinocytes directly into chronic and third-degree wounds (Pham, Sharma and Mikos 1198).

Another method of isolation involves dermal substitutes as compared to epidermal substitutes. To treat full-thickness lesions that affect both the dermis and the epidermis. The use of an allograft or dermal constructs is necessary for these situations. Dermal substitutes are developed through natural or synthetic techniques. They tend to prevent the contraction of the wound and provide mechanical stability. For instance, the process involves engineering tissues using such procedures as loading dermal substitutes with complexes of plasmid DNA that encodes for VEGF-165/N,N,N-trimethyl chotisan chloride (Cancedda et al. 83). Testing for regeneration of the full-thickness wounds in animal models as well as in humans has shown that the process is faster and more effective, making it an important approach to healing these wounds (MacNeil 876).

Don't use plagiarized sources. Get Your Custom Essay on
Epidermal substitutes are used for treating lesions that have affected the dermis
Just from $13/Page
Order Essay
Assignment Help Guys
Calculate your paper price
Pages (550 words)
Approximate price: -

Why Work with Us

Top Quality and Well-Researched Papers

We always make sure that writers follow all your instructions precisely. You can choose your academic level: high school, college/university or professional, and we will assign a writer who has a respective degree.

Professional and Experienced Academic Writers

We have a team of professional writers with experience in academic and business writing. Many are native speakers and able to perform any task for which you need help.

Free Unlimited Revisions

If you think we missed something, send your order for a free revision. You have 10 days to submit the order for review after you have received the final document. You can do this yourself after logging into your personal account or by contacting our support.

Prompt Delivery and 100% Money-Back-Guarantee

All papers are always delivered on time. In case we need more time to master your paper, we may contact you regarding the deadline extension. In case you cannot provide us with more time, a 100% refund is guaranteed.

Original & Confidential

We use several writing tools checks to ensure that all documents you receive are free from plagiarism. Our editors carefully review all quotations in the text. We also promise maximum confidentiality in all of our services.

24/7 Customer Support

Our support agents are available 24 hours a day 7 days a week and committed to providing you with the best customer experience. Get in touch whenever you need any assistance.

Try it now!

Calculate the price of your order

Total price:

How it works?

Follow these simple steps to get your paper done

Place your order

Fill in the order form and provide all details of your assignment.

Proceed with the payment

Choose the payment system that suits you most.

Receive the final file

Once your paper is ready, we will email it to you.

Our Services

No need to work on your paper at night. Sleep tight, we will cover your back. We offer all kinds of writing services.


Essay Writing Service

No matter what kind of academic paper you need and how urgent you need it, you are welcome to choose your academic level and the type of your paper at an affordable price. We take care of all your paper needs and give a 24/7 customer care support system.


Admission Essays & Business Writing Help

An admission essay is an essay or other written statement by a candidate, often a potential student enrolling in a college, university, or graduate school. You can be rest assurred that through our service we will write the best admission essay for you.


Editing Support

Our academic writers and editors make the necessary changes to your paper so that it is polished. We also format your document by correctly quoting the sources and creating reference lists in the formats APA, Harvard, MLA, Chicago / Turabian.


Revision Support

If you think your paper could be improved, you can request a review. In this case, your paper will be checked by the writer or assigned to an editor. You can use this option as many times as you see fit. This is free because we want you to be completely satisfied with the service offered.

error: Content is protected !!
Open chat
Need assignment help? You can contact our live agent via WhatsApp using +1 718 717 2861

Feel free to ask questions, clarifications, or discounts available when placing an order.