Researchers on centriole rediblication and genome instability provided the basis for the given study. Thus, previous results provide that centrosomes, like DNA, are duplicated only once per cell cycle (Wong and Stearns, 2003). The study provided by Nigg (2006) assumes that there is a correlation between excess centrosomes, aneuploidy, and cancer (which is a mutation of cells). However, the causes and consequence of these correlations are unclear. Thus, understanding of the cells regulatory mechanisms is important to understand the work of the robust mechanism in cells that blocks the reduplication (Hinchcliffe et al. 1998, Wong and Stearns 2003, Tsou and Stearns 2006b ). According to the studies provided by Blow and Dutta (2005 ). Deshaies, 1999 and DePamphilis et al., 2006, The DNA replication can provide an insight into this process. In the S phase, there are several active mechanisms that prevent the DNA replication. The E3 ubiquitin ligases limits the destruction of the replication-initiation factors (DePamphilis et al. 2006).
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